Vitamin C Intake Adequacy and the Incidence of Anemia in Pregnant Women: A Cross-Sectional Study at Puskesmas Totoli, Majene Regency, West Sulawesi
A Cross-Sectional Study at Puskesmas Totoli, Majene Regency, West Sulawesi
Article History
Submited : May 13, 2026
Published : May 17, 2026
Anemia during pregnancy constitutes a major public health concern in Indonesia, with inadequate micronutrient intak, particularly vitamin C, identified as a key contributing factor. Vitamin C (ascorbic acid) facilitates the absorption of non-heme iron, thereby playing a critical role in hemoglobin synthesis. This study aimed to examine the relationship between vitamin C intake adequacy and the incidence of anemia among pregnant women in the working area of Puskesmas Totoli, Majene Regency, West Sulawesi. A cross-sectional observational design was employed, involving 106 pregnant women in the first and second trimesters selected via simple random sampling. Dietary assessment was conducted using the Semi-Quantitative Food Frequency Questionnaire (SQ-FFQ), hemoglobin levels were measured using the Easy Touch GCHb digital device, and anemia was defined based on the Indonesian Ministry of Health criteria (Hb <11 g/dL for trimesters I and III; <10.5 g/dL for trimester II). Results indicated that 34.9% of subjects were anemic, and 46.2% had inadequate vitamin C intake (mean: 57.18 mg/day; AKG 2019 recommendation: ≥95 mg/day during pregnancy). Among subjects with inadequate vitamin C, 51.0% were anemic, compared to 21.1% among those with adequate vitamin C. Bivariate analysis using the Chi-square test revealed a statistically significant association between vitamin C adequacy and the incidence of anemia (p = 0.001). These findings underscore the importance of improving vitamin C consumption through fruit, vegetable, and dietary diversification programs to support iron absorption and reduce anemia risk during pregnancy
- World Health Organization. WHO global anaemia estimates. Switzerland ; 2025.
- Stevens GA, Finucane MM, De-Regil LM, Paciorek CJ, Flaxman SR, Branca F, et al. Global, regional, and national trends in haemoglobin concentration and prevalence of total and severe anaemia in children and pregnant and non-pregnant women for 1995–2011: a systematic analysis of population-representative data. Lancet Glob Health. 2013;1(1):e16–25.
- Benson CS, Shah A, Frise MC, Frise CJ. Iron deficiency anaemia in pregnancy: a contemporary review. Obstet Med. 2021;14(2):67–76.
- Kementrian Kesehatan Republik Indonesia. Laporan Nasional Riskesdas 2018. Jakarta; 2018.
- Kementrian Kesehatan. Survei Kesehatan Indonesia Tahun 2023 [Internet]. Jakarta; 2023 [cited 2025 Dec 27]. Available from: https://drive.google.com/file/d/1rjNDG_f8xG6-Y9wmhJUnXhJ-vUFevVJC/view
- Stevens GA, Paciorek CJ, Flores-Urrutia MC, Borghi E, Namaste S, Wirth JP, et al. National, regional, and global estimates of anaemia by severity in women and children for 2000-19: a pooled analysis of population-representative data. Lancet Glob Health. 2022 May;10(5):e627–39. doi:10.1016/S2214-109X(22)00084-5 PubMed PMID: 35427520.
- Young MF, Oaks BM, Rogers HP, Tandon S, Martorell R, Dewey KG, et al. Maternal low and high hemoglobin concentrations and associations with adverse maternal and infant health outcomes: an updated global systematic review and meta-analysis. BMC Pregnancy Childbirth. 2023;23(1):264. doi:10.1186/s12884-023-05489-6
- Piskin E, Cianciosi D, Gulec S, Tomas M, Capanoglu E. Iron absorption: factors, limitations, and improvement methods. ACS Omega. 2022;7(24):20441–56.
- Milman NT. A review of nutrients and compounds, which promote or inhibit intestinal iron absorption: making a platform for dietary measures that can reduce iron uptake in patients with genetic haemochromatosis. J Nutr Metab. 2020;2020(1):7373498.
- Kementerian Kesehatan Republik Indonesia. Peraturan Menteri Kesehatan Nomor 28 Tahun 2019 tentang Angka Kecukupan Gizi yang Dianjurkan untuk Masyarakat Indonesia. Kementerian Kesehatan Republik Indonesia [Internet]. 2019 [cited 2026 May 13]. Available from: https://peraturan.bpk.go.id/Details/138621/permenkes-no-28-tahun-2019
- Agustina R, Rianda D, Lasepa W, Birahmatika FS, Stajic V, Mufida R. Nutrient intakes of pregnant and lactating women in Indonesia and Malaysia: Systematic review and meta-analysis. Front Nutr. 2023;10:1030343. doi:10.3389/fnut.2023.1030343 PubMed PMID: 37063336.
- Madanijah S, Briawan D, Rimbawan R, Zulaikhah Z, Andarwulan N, Nuraida L, et al. Nutritional status of pre-pregnant and pregnant women residing in Bogor district, Indonesia: a cross-sectional dietary and nutrient intake study. British Journal of Nutrition. 2016/04/15. 2016;116(S1):S57–66. doi:DOI: 10.1017/S000711451600057X
- Tanziha I, Damanik MRM, Utama LJ, Rosmiati R. Faktor risiko anemia ibu hamil di indonesia. 2017.
- Kemenkes. Buku Saku Pencegahan Anemia Pada Ibu Hami. 2023. 1–47 p.
- Samuel S, Darebo T, Desta DT, Mulugeta A. Socio-economic and dietary diversity characteristics are associated with anemia among pregnant women attending antenatal care services in public health centers of Kembata Tembaro Zone, Southern Ethiopia. Food Sci Nutr. 2020 Apr;8(4):1978–86. doi:10.1002/fsn3.1485 PubMed PMID: 32328264.
- Rotella R, Soriano JM, Llopis-González A, Morales-Suarez-Varela M. The Impact of Moringa oleifera Supplementation on Anemia and other Variables during Pregnancy and Breastfeeding: A Narrative Review. Nutrients. 2023 Jun;15(12). doi:10.3390/nu15122674 PubMed PMID: 37375577.
- Cahyani KR, Mataram IIKA, SKM IAEP. Hubungan Pengetahuan dan Tingkat Konsumsi Zat Besi, Asam Folat, Vitamin C, Protein dan Energi Dengan Kejadian Anemia Ibu Hamil Di Puskesmas Seririt 1 Kabupaten Buleleng. Jurnal Ilmu Gizi: Journal of Nutrition Science. 2025;14(1):22–30.
- Salsabil IS, Nadhiroh SR. Literature review: hubungan asupan protein, vitamin c, dan zat besi dengan kejadian anemia pada remaja putri. Media Gizi Kesmas. 2023;12(1):516–21.
- Seid A, Dugassa Fufa D, Weldeyohannes M, Tadesse Z, Fenta SL, Bitew ZW, et al. Inadequate dietary diversity during pregnancy increases the risk of maternal anemia and low birth weight in Africa: A systematic review and meta-analysis. Food Sci Nutr. 2023 Jul;11(7):3706–17. doi:10.1002/fsn3.3388 PubMed PMID: 37457158.
- Putri, W. A., Widianto, D., Amrinanto, A. H., Anggiruling, D. O., Fitridewi, P. B., & Putri, A. N. (2025). Association Between Nutritional Adequacy Level and Iron-Folic Acid (IFA) Tablet Consumption with Anemia Incidence in Pregnant Women. Journal of Global Nutrition, 5(2), 617-625.
- Ibnu, I. N., Perdana, S. M., & Kasyani, K. (2025). Factors Associated with the Incidence of Anemia in Pregnant Women at Risk of Stunting in Batanghari Regency. Journal of Global Nutrition, 5(1), 504-511.
Copyright (c) 2026 Journal of Global Nutrition

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.